Poor oral health as a risk factor for esophageal squamous dysplasia in Northeastern Iran
Identifieur interne : 000250 ( France/Analysis ); précédent : 000249; suivant : 000251Poor oral health as a risk factor for esophageal squamous dysplasia in Northeastern Iran
Auteurs : Alireza Sepehr [États-Unis] ; Farin Kamangar [États-Unis] ; Saman Fahimi [France] ; Farrokh Saidi [Iran] ; Christian C. Abnet [États-Unis] ; Sanford M. Dawsey [États-Unis]Source :
- Anticancer research [ 0250-7005 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Wicri :
- geographic : Iran.
English descriptors
- KwdEn :
Abstract
Background: Northeastern Iran has one of the highest rates of esophageal squamous cell carcinoma (ESCC) in the world. The reasons for observing such high rates of ESCC in this area are not fully clear. The current study evaluates the association between some potential risk factors and squamous dysplasia, a precursor lesion of ESCC, in northeastern Iran. Materials and Methods: Using logistic regression, we compared potential risk factors of ESCC in 124 individuals with dysplasia and 50 normal individuals from northeastern Iran. Case/control status was histologically proven in all 174 study participants. Results: Poor oral health showed a dose-response association with ESCC risk (p for trend < 0.01). Edentulous individuals had 5-fold higher risk of dysplasia compared to participants with good oral health (p-value < 0.01). Conclusion: Our results are consistent with two other published studies that have shown oral health as a risk factor for ESCC. The high incidence of ESCC in northeastern Iran may be partly attributable to poor oral health.
Affiliations:
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Abnet</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, 6116 Executive Blvd., Suite 705</s1><s2>Bethesda, MD, 21218</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD, 21218</wicri:noRegion></affiliation></author><author><name sortKey="Dawsey, Sanford M" sort="Dawsey, Sanford M" uniqKey="Dawsey S" first="Sanford M." last="Dawsey">Sanford M. Dawsey</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, 6116 Executive Blvd., Suite 705</s1><s2>Bethesda, MD, 21218</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Bethesda, MD, 21218</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Anticancer research</title><title level="j" type="abbreviated">Anticancer res.</title><idno type="ISSN">0250-7005</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Anticancer research</title><title level="j" type="abbreviated">Anticancer res.</title><idno type="ISSN">0250-7005</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cancerology</term><term>Dental disease</term><term>Dysplasia</term><term>Epidemiology</term><term>Esophagus cancer</term><term>Iran</term><term>Oral cavity</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dent pathologie</term><term>Cavité buccale</term><term>Facteur risque</term><term>Dysplasie</term><term>Epidémiologie</term><term>Iran</term><term>Cancer oesophage</term><term>Cancérologie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Iran</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Northeastern Iran has one of the highest rates of esophageal squamous cell carcinoma (ESCC) in the world. The reasons for observing such high rates of ESCC in this area are not fully clear. The current study evaluates the association between some potential risk factors and squamous dysplasia, a precursor lesion of ESCC, in northeastern Iran. Materials and Methods: Using logistic regression, we compared potential risk factors of ESCC in 124 individuals with dysplasia and 50 normal individuals from northeastern Iran. Case/control status was histologically proven in all 174 study participants. Results: Poor oral health showed a dose-response association with ESCC risk (p for trend < 0.01). Edentulous individuals had 5-fold higher risk of dysplasia compared to participants with good oral health (p-value < 0.01). Conclusion: Our results are consistent with two other published studies that have shown oral health as a risk factor for ESCC. The high incidence of ESCC in northeastern Iran may be partly attributable to poor oral health.</div></front></TEI><affiliations><list><country><li>France</li><li>Iran</li><li>États-Unis</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Massachusetts</li><li>Rhône-Alpes</li></region><settlement><li>Lyon</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Sepehr, Alireza" sort="Sepehr, Alireza" uniqKey="Sepehr A" first="Alireza" last="Sepehr">Alireza Sepehr</name></noRegion><name sortKey="Abnet, Christian C" sort="Abnet, Christian C" uniqKey="Abnet C" first="Christian C." last="Abnet">Christian C. Abnet</name><name sortKey="Dawsey, Sanford M" sort="Dawsey, Sanford M" uniqKey="Dawsey S" first="Sanford M." last="Dawsey">Sanford M. Dawsey</name><name sortKey="Kamangar, Farin" sort="Kamangar, Farin" uniqKey="Kamangar F" first="Farin" last="Kamangar">Farin Kamangar</name><name sortKey="Sepehr, Alireza" sort="Sepehr, Alireza" uniqKey="Sepehr A" first="Alireza" last="Sepehr">Alireza Sepehr</name></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Fahimi, Saman" sort="Fahimi, Saman" uniqKey="Fahimi S" first="Saman" last="Fahimi">Saman Fahimi</name></region></country><country name="Iran"><noRegion><name sortKey="Saidi, Farrokh" sort="Saidi, Farrokh" uniqKey="Saidi F" first="Farrokh" last="Saidi">Farrokh Saidi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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